|
|Section2= |Section3= }} Fructose 2,6-bisphosphate abbreviated Fru-2,6-''P''2, is a metabolite that allosterically affects the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis. Fru-2,6-''P''2 is synthesized and broken down by the bifunctional enzyme phosphofructokinase 2/fructose-2,6-bisphosphatase (PFK-2/FBPase-2). The synthesis of Fru-2,6-''P''2 is performed through the phosphorylation of fructose 6-phosphate using ATP by the PFK-2 portion of the enzyme. The breakdown of Fru-2,6-''P''2 is catalyzed by dephosphorylation by FBPase-2 to produce Fructose 6-phosphate and Pi. Reaction scheme of breakdown of fructose 2,6-bisphosphate to fructose 6-phosphate.〔(KEGG REACTION: R02730 )〕 ==Effects on glucose metabolism== Fru-2,6-''P''2 strongly activates glucose breakdown in glycolysis through allosteric modulation of phosphofructokinase 1 (PFK-1). Elevated expression of Fru-2,6-''P''2 levels in the liver allosterically activates phosphofructokinase 1 by increasing the enzyme’s affinity for fructose 6-phosphate, while decreasing its affinity for inhibitory ATP and citrate. At physiological concentration, PFK-1 is almost completely inactive, but interaction with Fru-2,6-''P''2 activates the enzyme to stimulate glycolysis and enhance breakdown of glucose.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Fructose 2,6-bisphosphate」の詳細全文を読む スポンサード リンク
|